I'll concur on the spacey quotes. Twister  has a tab just for those.
You pick whether to visit all quotes or only anomalies, based on
spacing restarting every paragraph. I never bother to visit all any
more. It just pops from one bad quote-pair to the next, highlights
the whole thing, and offers a button to realign it correctly. If it's
just a spacing problem, not missing one end or the other; or
some other usage (e.g. inches, dittos, etc.) it always gets it
right. This is probably the fastest of all the regex checks that
require visual inspection.